SAKK - Young oncologist academy — Was junge Onkologen von ESMO - EHA und ESTRO berichten
Advancing precision treatment for GI malignancies
Upper GI Keynote-811 Since 2009, trastuzumab combined with chemotherapy has been the standard of care for HER2-positive metastatic gastric cancer (mG) and gastroesophageal junction cancer (GEJ), based on the results of the phase 3 ToGA trial (1). In recent years, integrating tumor-specific antibodies with PD-1 inhibitors, has demonstrated enhanced immune infiltration and T-cell response in preclinical studies, effectively countering tolerogenic dendritic cells (2).