At this year’s ESMO 2024 annual meeting, two pivotal phase 3 trials investigating pembrolizumab in advanced non-metastatic gynecologic cancers were presented, potentially changing the treatment landscape in both cervical and endometrial cancer.
This study presents the findings of the first-in-human investigation of the mRNA-based cancer vaccine CVGBM in patients with newly diagnosed, surgically resected, and MGMT-unmethylated glioblastoma, (GBM), a group historically characterized by poor prognosis and limited treatment options (1).
Recent advances in breast cancer research have shown practice changing findings. This review article wants to highlight key insights from three major breast cancer trials presented at the last 2024 ESMO congress: the HypoG-01 trial, which evaluated hypofractionated radiotherapy in localized breast cancer requiring nodal irradiation, the KEYNOTE-522 trial, which investigated the addition of pembrolizumab to chemotherapy in localized node positive triple-negative breast cancer (TNBC), and the NATALEE trial, which assessed adjuvant ribociclib in hormone receptor-positive high risk early breast cancer. These studies contribute to ongoing developments in personalized treatment strategies across various breast cancer subtypes.
Many interesting studies in the field of prostate cancer (PC) were presented at ESMO 2024. In my opinion three studies deserve to be highlighted: one in the localized setting, one in the metastatic hormone-sensitive setting (mHSPC) and one in the metastatic castration resistant setting (mCRPC).
There were many new developments, including practice-changing clinical trials, presented at this year’s European Society of Medical Oncology (ESMO) Congress in Barcelona. From the vast number of abstracts available in the rapidly evolving field of thoracic oncology, we have selected one abstract that was of particular interest to us: Low-dose versus standard dose pembrolizumab for treatment of advanced-stage non-small cell lung cancer (NSCLC) – Results of the pre-planned interim analysis of the clinical trial NVALT-30
Neoadjuvant therapies have the potential to increase R0 resectability and thereby improving surgical outcomes. Two recent phase II trials, PANDAS/PRODIGE 44 (1) and NICHE-2 (2), investigated neoadjuvant treatment approaches for borderline resectable pancreatic cancer and locally advanced mismatch-repair deficient (dMMR) colon cancer, respectively, with notable implications for clinical practice.
Since 2009, trastuzumab combined with chemotherapy has been the standard of care for HER2-positive metastatic gastric (mGC) and gastroesophageal junction cancer (GEJ), based on findings from the phase 3 ToGA trial (1). However, despite this initial success, the following decade brought a series of negative phase 3 trials, leaving first-line treatment options for HER2-positive gastric and gastroesophageal cancers without significant advancements (2–5).
At ESMO 2024 in Barcelona, various studies regarding the management of non-muscle-invasive bladder cancer (NMIBC), muscle-invasive bladder cancer (MIBC) and locally advanced / metastatic (la/m) bladder cancer were presented. This article aims to give a short overview of one outstanding study of each group.
Beim ESMO-Jahreskongress wurden in mehreren spezialisierten Vortragssitzungen Fortschritte für die Behandlung urologischer Tumoren gezeigt. In zwei Präsidentensitzungen konnten Studien mit praxisverändernden Ergebnissen in der UroOnkologie überzeugen. Als Late-Breaking-Abstract Nummer 1 stellte Prof. Dr. Silke Gillessen, Bellinzona, die Ergebnisse der PEACE-3-Studie vor.
Immuntherapien und zielgerichtete Therapien, aber auch Hormon- und Chemotherapien bilden die Säulen der medikamentösen Krebstherapie bei gynäkologischen Tumoren. Dass alle diese Bereiche wichtig sind und weiterentwickelt werden, zeigt die derzeitige Studienlandschaft. Im Folgenden eine Auswahl wichtiger gynäkologischer Studien von der ESMO-Jahrestagung.